Detalhe da pesquisa
1.
Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer.
Nature
; 578(7794): 306-310, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31969702
2.
Selective Inhibition of the Second Bromodomain of BET Family Proteins Results in Robust Antitumor Activity in Preclinical Models of Acute Myeloid Leukemia.
Mol Cancer Ther
; 20(10): 1809-1819, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34253595
3.
Progesterone receptors upregulate Wnt-1 to induce epidermal growth factor receptor transactivation and c-Src-dependent sustained activation of Erk1/2 mitogen-activated protein kinase in breast cancer cells.
Mol Cell Biol
; 27(2): 466-80, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17074804
4.
Scaffolding actions of membrane-associated progesterone receptors.
Steroids
; 74(7): 568-72, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19135465
5.
Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors.
Mol Endocrinol
; 22(4): 823-37, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18202149
6.
Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells.
Mol Endocrinol
; 21(12): 2890-906, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17717077
7.
Linkage of progestin and epidermal growth factor signaling: phosphorylation of progesterone receptors mediates transcriptional hypersensitivity and increased ligand-independent breast cancer cell growth.
Steroids
; 72(2): 188-201, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17173941
8.
Exploitation of Castration-Resistant Prostate Cancer Transcription Factor Dependencies by the Novel BET Inhibitor ABBV-075.
Mol Cancer Res
; 15(1): 35-44, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27707886
9.
Vulnerability of Small-Cell Lung Cancer to Apoptosis Induced by the Combination of BET Bromodomain Proteins and BCL2 Inhibitors.
Mol Cancer Ther
; 16(8): 1511-1520, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28468776
10.
Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies.
Cancer Res
; 77(11): 2976-2989, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28416490
11.
Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.
J Med Chem
; 60(20): 8369-8384, 2017 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28949521
12.
A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver.
Elife
; 42015 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26653140
13.
Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development.
Dev Cell
; 21(2): 315-27, 2011 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-21820362
14.
Decreased recognition of SUMO-sensitive target genes following modification of SF-1 (NR5A1).
Mol Cell Biol
; 28(24): 7476-86, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18838537
15.
Regulated association of protein kinase B/Akt with breast tumor kinase.
J Biol Chem
; 280(3): 1982-91, 2005 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15539407